<?xml version="1.0" encoding="utf8"?>
 <!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.0 20120330//EN" "http://jats.nlm.nih.gov/publishing/1.0/JATS-journalpublishing1.dtd"> <article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="literature-review" dtd-version="1.0" xml:lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JPHI</journal-id>
      <journal-title-group>
        <journal-title>Journal of Public Health International</journal-title>
      </journal-title-group>
      <issn pub-type="epub">2641-4538</issn>
      <publisher>
        <publisher-name>Open Access Pub</publisher-name>
        <publisher-loc>United States</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">JPHI-25-5436</article-id>
      <article-id pub-id-type="doi">10.14302/issn.2641-4538.jphi-25-5436</article-id>
      <article-categories>
        <subj-group>
          <subject>literature-review</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Health Practitioner Burnout, Safety Implications, and Programmatic Fixes: A Systematic Literature Review of Current Literature Reviews—200 Proof*</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Ralph</surname>
            <given-names>J Johnson</given-names>
          </name>
          <xref ref-type="aff" rid="idm1840382164">1</xref>
          <xref ref-type="aff" rid="idm1840382884">*</xref>
        </contrib>
      </contrib-group>
      <aff id="idm1840382164">
        <label>1</label>
        <addr-line>Research PA-C/Research Coordinator University of Texas MD Anderson Cancer Center. Chaplain Texas Medical Center Catholic Chaplaincy Corps.</addr-line>
      </aff>
      <aff id="idm1840382884">
        <label>*</label>
        <addr-line>Corresponding Author </addr-line>
      </aff>
      <author-notes>
        <corresp>
    
    Ralph J Johnson, <addr-line>Research PA-C/Research Coordinator University of Texas MD Anderson Cancer Center. Chaplain Texas Medical Center Catholic Chaplaincy Corps</addr-line>, <email>jayjohnson131313@gmail.com</email></corresp>
        <fn fn-type="conflict" id="idm1842198316">
          <p>The authors have no conflict of interest to declare.</p>
        </fn>
      </author-notes>
      <pub-date pub-type="epub" iso-8601-date="2025-02-27">
        <day>27</day>
        <month>02</month>
        <year>2025</year>
      </pub-date>
      <volume>7</volume>
      <issue>3</issue>
      <fpage>14</fpage>
      <lpage>27</lpage>
      <history>
        <date date-type="received">
          <day>10</day>
          <month>02</month>
          <year>2025</year>
        </date>
        <date date-type="accepted">
          <day>18</day>
          <month>02</month>
          <year>2025</year>
        </date>
        <date date-type="online">
          <day>27</day>
          <month>02</month>
          <year>2025</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>©</copyright-statement>
        <copyright-year>2025</copyright-year>
        <copyright-holder>Ralph J Johnson</copyright-holder>
        <license xlink:href="http://creativecommons.org/licenses/by/4.0/" xlink:type="simple">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
        </license>
      </permissions>
      <self-uri xlink:href="http://openaccesspub.org/jphi/article/2187">This article is available from http://openaccesspub.org/jphi/article/2187</self-uri>
      <abstract>
        <p>High rates of workplace psychological stress and burnout have been chronic among Healthcare Practitioners. Research shows that Healthcare Practitioner  psychological stress / burnout is related to poor quality of care and a high              probability of making medical errors and mishaps resulting in harm to patients and even workers themselves. In response, relatively impactful programs have been developed to address Practitioner burnout. To derive a better understanding of the subject and inform best practices and policy regarding the problem and its fixes, this article reports findings from a novel study of a systematic (PRISMA-based) literature review of current (circa ~10 years &lt;) literature reviews; or a  distillation of reviews already at 100 proof then undergoing a further distillation into a review of 200 proof.* This study employed a grounded theoretic qualitative methodology to iteratively generate and enumerate descriptive themes from the study’s literature review articles. This article reports on what is currently known regarding the precipitants of Health Practitioner Burnout, Burnout itself, its                  relationship to Safety lapses and mishaps, and Programmatic Interventions (i.e., Fixes). The primary conclusion is that Health Practitioners are the foundation of healthcare organizations and key to quality care and management / leadership should be concerned for their wellbeing; and this article provides a general                 blueprint in terms of addressing burnout and safety. Study Limitations and Future research are also discussed.</p>
      </abstract>
      <kwd-group>
        <kwd>Health Care Practitioners</kwd>
        <kwd>Health Workers</kwd>
        <kwd>Psychological Stress</kwd>
        <kwd>Burnout</kwd>
        <kwd>Safety</kwd>
        <kwd>Adverse Events</kwd>
        <kwd>Interventions</kwd>
        <kwd>CBT</kwd>
        <kwd>Mindfulness</kwd>
        <kwd>Resilience</kwd>
        <kwd>Culture of Safety</kwd>
      </kwd-group>
      <counts>
        <fig-count count="2"/>
        <table-count count="3"/>
        <page-count count="14"/>
      </counts>
    </article-meta>
  </front>
  <body>
    <sec id="idm1840246156" sec-type="intro">
      <title>Introduction / Background</title>
      <p>Considerable concern regarding Healthcare Practitioner burnout and related               secondary mental distress (e.g., anxiety, depression, depersonalization, emotional exhaustion, disengagement, etc…) continues to be voiced.<xref ref-type="bibr" rid="ridm1841464676">1</xref><xref ref-type="bibr" rid="ridm1841468500">2</xref> Though the issue is complex and multi-faceted, research has reported widespread levels of burnout that are substantially higher for Health Care Practitioners than the general population regardless of demographic characteristics and other personal factors.<xref ref-type="bibr" rid="ridm1841468500">2</xref> For example, there are estimates of more than half the nurses working in the U.S. and one in ten worldwide experience burnout with other health professions more or less mirroring these rates.<xref ref-type="bibr" rid="ridm1841468500">2</xref>, (also see <xref ref-type="bibr" rid="ridm1841308572">3</xref><xref ref-type="bibr" rid="ridm1841311956">4</xref><xref ref-type="bibr" rid="ridm1841298748">5</xref><xref ref-type="bibr" rid="ridm1841285036">6</xref>) Reports in the literature                 suggest that those in the healthcare field, in general, and frontline practitioners like nurses specifically, are particularly prone to burnout and psychological                 ill-health due to extraordinary workloads, emotional draining demands, and work conditions.<xref ref-type="bibr" rid="ridm1841464676">1</xref><xref ref-type="bibr" rid="ridm1841468500">2</xref><xref ref-type="bibr" rid="ridm1841311956">4</xref><xref ref-type="bibr" rid="ridm1841298748">5</xref><xref ref-type="bibr" rid="ridm1841285036">6</xref><xref ref-type="bibr" rid="ridm1841287556">7</xref><xref ref-type="bibr" rid="ridm1841258260">8</xref><xref ref-type="bibr" rid="ridm1841252428">9</xref></p>
      <p>A paramount concern is that Healthcare Practitioners experiencing a high degree of psychological              distress and burnout may be inattentive and prone to medical errors endangering patients and even themselves or co-workers.<xref ref-type="bibr" rid="ridm1841468500">2</xref><xref ref-type="bibr" rid="ridm1841298748">5</xref><xref ref-type="bibr" rid="ridm1841285036">6</xref><xref ref-type="bibr" rid="ridm1841287556">7</xref><xref ref-type="bibr" rid="ridm1841258260">8</xref><xref ref-type="bibr" rid="ridm1841252428">9</xref><xref ref-type="bibr" rid="ridm1841236620">10</xref><xref ref-type="bibr" rid="ridm1841235972">11</xref><xref ref-type="bibr" rid="ridm1841228196">12</xref><xref ref-type="bibr" rid="ridm1841210660">13</xref><xref ref-type="bibr" rid="ridm1841205476">14</xref><xref ref-type="bibr" rid="ridm1841213036">15</xref> Compounding this concern are other healthcare organizational-level effects and astronomical costs of burnout such as disengagement and diminished productivity, intention to leave, turnover, attrition, and erosion of team morale. <xref ref-type="bibr" rid="ridm1841468500">2</xref><xref ref-type="bibr" rid="ridm1841228196">12</xref><xref ref-type="bibr" rid="ridm1841213036">15</xref> Indeed, the problem of Healthcare Practitioner burnout, safety, and their fixes is so staggering that hundreds of peer-reviewed research studies have been published regarding various aspects. This then raises the question of how to best address the problem.<xref ref-type="bibr" rid="ridm1841464676">1</xref><xref ref-type="bibr" rid="ridm1841311956">4</xref><xref ref-type="bibr" rid="ridm1841298748">5</xref><xref ref-type="bibr" rid="ridm1841285036">6</xref><xref ref-type="bibr" rid="ridm1841287556">7</xref><xref ref-type="bibr" rid="ridm1841258260">8</xref><xref ref-type="bibr" rid="ridm1841236620">10</xref><xref ref-type="bibr" rid="ridm1841235972">11</xref><xref ref-type="bibr" rid="ridm1841210660">13</xref><xref ref-type="bibr" rid="ridm1841210804">16</xref><xref ref-type="bibr" rid="ridm1841176572">17</xref><xref ref-type="bibr" rid="ridm1841169804">18</xref><xref ref-type="bibr" rid="ridm1841158148">19</xref><xref ref-type="bibr" rid="ridm1841153180">20</xref><xref ref-type="bibr" rid="ridm1841146988">21</xref>.</p>
      <p>The subject of Healthcare Practitioner psychological stress, burnout, safety implications, and                  ameliorative interventions coincided with the advent and development of electronic medical literature repositories and databases such as PubMed, Cochranes, Psych Lit, Google Scholar, and Scopious—to name a few. <xref ref-type="bibr" rid="ridm1841464676">1</xref><xref ref-type="bibr" rid="ridm1841468500">2</xref><xref ref-type="bibr" rid="ridm1841298748">5</xref><xref ref-type="bibr" rid="ridm1841258260">8</xref><xref ref-type="bibr" rid="ridm1841252428">9</xref><xref ref-type="bibr" rid="ridm1841236620">10</xref><xref ref-type="bibr" rid="ridm1841235972">11</xref><xref ref-type="bibr" rid="ridm1841228196">12</xref><xref ref-type="bibr" rid="ridm1841205476">14</xref><xref ref-type="bibr" rid="ridm1841210804">16</xref><xref ref-type="bibr" rid="ridm1841176572">17</xref><xref ref-type="bibr" rid="ridm1841169804">18</xref><xref ref-type="bibr" rid="ridm1841158148">19</xref><xref ref-type="bibr" rid="ridm1841153180">20</xref><xref ref-type="bibr" rid="ridm1841146988">21</xref> Their accelerated, comprehensive, and thorough literature search engines vastly enhanced the ability to conduct more comprehensive yet exacting and systematic reviews of the scholarly literature regarding the subject. <xref ref-type="bibr" rid="ridm1841308572">3</xref><xref ref-type="bibr" rid="ridm1841285036">6</xref><xref ref-type="bibr" rid="ridm1841258260">8</xref><xref ref-type="bibr" rid="ridm1841236620">10</xref><xref ref-type="bibr" rid="ridm1841235972">11</xref><xref ref-type="bibr" rid="ridm1841213036">15</xref><xref ref-type="bibr" rid="ridm1841210804">16</xref><xref ref-type="bibr" rid="ridm1841169804">18</xref><xref ref-type="bibr" rid="ridm1841153180">20</xref><xref ref-type="bibr" rid="ridm1841146988">21</xref></p>
      <p>In order to provide a current and more formative grasp regarding the state of the research on the subject matter of Healthcare Practitioner psychological distress and burnout, safety implications, and corrective interventions, the intent of this article is to report findings from a novel study that conducted a theoretic grounded qualitative systematic <xref ref-type="bibr" rid="ridm1841141588">22</xref> literature review of literature reviews in the past 10 years or less. The uniqueness of this study is there are so few systematic literature reviews on literature reviews in the scientific scholarly literature it is extremely difficult to pin down a number and they are not                 considered a category of review in the health field.<xref ref-type="bibr" rid="ridm1841140580">23</xref> This report considers the following components of the burnout, safety, and intervention “equation” in their logical sequence: (1) Contributing                 Work-related Precipitants; (2) Psychological Distress / Burnout; (3) Safety Implications / Mishaps; and (4) Interventions (see Process Diagram 1). </p>
      <fig id="idm1842237932">
        <graphic xlink:href="images/image1.jpg" mime-subtype="jpg"/>
      </fig>
      <p>This diagram shows a process model of (1) the precipitants of Psychological Distress and Burnout            leading to, (2) the condition of Psychological Distress / Burnout, which in turn leads to Safety mishaps. The dashed line depicts the tenuousness of that relationship between (2) and (3). And finally (4) depicts the Intervention Programs breaking the connection between (1) and (2) by addressing / disrupting the precipitant conditions necessary for Psychological Distress / Burnout to occur and at minimum              reasonably containing them. </p>
    </sec>
    <sec id="idm1840244428" sec-type="methods">
      <title>Method</title>
      <p>The aim of a literature review of peer-reviewed literature reviews on Healthcare Practitioner burnout, safety, and its fixes is to create a further synthesis / purification of the scientific and best practices             literature, or put differently, a further distillation from 100 proof into near-200 proof.* The hope was to highlight gaps in knowledge lending themselves to avenues for further inquiry and derive                           recommendations based on best practices to address the problem of increased burn-out and decreased safety in healthcare. </p>
      <p>This review generally adhered to the guidelines for Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA).<xref ref-type="bibr" rid="ridm1841141588">22</xref> The search of the scholarly literature for reviews used Key Words, variants, and Booleans: “Healthcare Providers,” “Healthcare Workers,” “Burnout, Safety,” and “Literature Review.” Since the study focused on the current state of the science, the literature search was restricted to the past 10 years; moreover, only peer-reviewed and English or translated into English literature review articles were considered for inclusion. The primary search engine that was used was PubMed, followed with a cross-check, by Medline, Good Scholar, Psych Lit, Cochrane, and Scopious; until subsequent searches proved to be overlapping, further searches were halted. Since the study            focused on the current state of the science, the literature search was restricted to the past 10 years; moreover, only peer-reviewed and English (or translated into English) literature review articles were considered for inclusion. Overlap was uncovered early on and duplicates were easily identified and            pre-excluded except for two articles, which were caught in subsequent examination and removed. In further subsequent examination, three more were excluded because they were deemed irrelevant. </p>
      <p>The literature search and examinations yielded 21 articles through the following systematic search and inclusion process (see Study PRISMA Diagram 2).</p>
      <fig id="idm1842243548">
        <graphic xlink:href="images/image2.jpg" mime-subtype="jpg"/>
      </fig>
      <p>Initially, 21 articles would appear insignificant and possibly unrepresentative. However, the 21                     articles—because they were literature reviews—actually represented an unduplicated count of 1, 266 peer-reviewed, scholarly, scientific, peer-reviewed articles related to various aspects of Healthcare Practitioner burnout, safety, and interventions. Nevertheless, some of the 21 articles did emphasize some aspects of burnout, safety and interventions more than others (see Article Different Emphases <xref ref-type="table" rid="idm1842242108">Table 1</xref>).</p>
      <table-wrap id="idm1842242108">
        <label>Table 1.</label>
        <caption>
          <title> Articles’ Different Emphases</title>
        </caption>
        <table rules="all" frame="box">
          <tbody>
            <tr>
              <th>
                <bold>Emphases</bold>
              </th>
              <td>
                <bold>Count</bold>
              </td>
            </tr>
            <tr>
              <td>Burnout</td>
              <td>11</td>
            </tr>
            <tr>
              <td>Safety</td>
              <td>12</td>
            </tr>
            <tr>
              <td>Interventions</td>
              <td>15</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
      <p><xref ref-type="table" rid="idm1842242108">Table 1</xref> shows that the literature review articles provided a general balanced coverage of the                        components of Burnout, Safety, and Intervention. </p>
      <p>It should be noted, the articles overwhelmingly represent Western Nation Health Practitioners (see <xref ref-type="table" rid="idm1842210764">Table 2</xref>), though one in the Britain category included a Third World comparison. </p>
      <table-wrap id="idm1842210764">
        <label>Table 2.</label>
        <caption>
          <title> Articles’ National Origin</title>
        </caption>
        <table rules="all" frame="box">
          <tbody>
            <tr>
              <th>
                <bold>Nation of Origin</bold>
              </th>
              <td>
                <bold>Count</bold>
              </td>
            </tr>
            <tr>
              <td>Britain (contained 3rd World comparison)</td>
              <td>11</td>
            </tr>
            <tr>
              <td>USA</td>
              <td>6</td>
            </tr>
            <tr>
              <td>Scotland</td>
              <td>2</td>
            </tr>
            <tr>
              <td>Switzerland</td>
              <td>1</td>
            </tr>
            <tr>
              <td>Total</td>
              <td>21</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
      <p>Though there was some balance achieved regarding the general representation of Health Practitioners’ vocations, there was an evident bias towards one type of Healthcare Practitioner vocation, namely, nurses (see <xref ref-type="table" rid="idm1842160556">Table 3</xref>).</p>
      <table-wrap id="idm1842160556">
        <label>Table 3.</label>
        <caption>
          <title> Articles’ Health Practitioner Vocations Focus</title>
        </caption>
        <table rules="all" frame="box">
          <tbody>
            <tr>
              <th>
                <bold>Health Practitioners’ Vocations Focus</bold>
              </th>
              <td>
                <bold>Count</bold>
              </td>
            </tr>
            <tr>
              <td>Healthcare Workers (includes nurses)</td>
              <td>11</td>
            </tr>
            <tr>
              <td>Nurses (specifically)</td>
              <td>8</td>
            </tr>
            <tr>
              <td>Radiographers</td>
              <td>1</td>
            </tr>
            <tr>
              <td>Physicians / Dentists</td>
              <td>1</td>
            </tr>
            <tr>
              <td>Total</td>
              <td>21</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
      <p>It is not surprising that nursing and nurses would be overrepresented. More research has been done on nursing / nurses as they are of greatest concern, because their role is vital to the provision of healthcare and they are the frontline Healthcare Practitioners; therefore, they experience higher precipitating              factors related to burnout and are in the position of making burnout-related inattentive critical safety mishaps. <xref ref-type="bibr" rid="ridm1841210660">13</xref><xref ref-type="bibr" rid="ridm1841176572">17</xref><xref ref-type="bibr" rid="ridm1841169804">18</xref><xref ref-type="bibr" rid="ridm1841158148">19</xref><xref ref-type="bibr" rid="ridm1841146988">21</xref> However, other types of Healthcare Practitioners are more and less at risk as the literature search revealed.<xref ref-type="bibr" rid="ridm1841468500">2</xref><xref ref-type="bibr" rid="ridm1841298748">5</xref><xref ref-type="bibr" rid="ridm1841285036">6</xref><xref ref-type="bibr" rid="ridm1841258260">8</xref><xref ref-type="bibr" rid="ridm1841236620">10</xref><xref ref-type="bibr" rid="ridm1841228196">12</xref><xref ref-type="bibr" rid="ridm1841210660">13</xref><xref ref-type="bibr" rid="ridm1841205476">14</xref><xref ref-type="bibr" rid="ridm1841213036">15</xref><xref ref-type="bibr" rid="ridm1841153180">20</xref> Notably, overall. the articles derived in the search and inclusion appeared to provide a strong representation of the subject under study. This               suggests that the findings from this study would be generalizable, and scientifically informed                  recommendations are advanced in the interest of best-practices. </p>
      <p>A grounded <xref ref-type="bibr" rid="ridm1841137340">24</xref><xref ref-type="bibr" rid="ridm1841132516">25</xref><xref ref-type="bibr" rid="ridm1841130284">26</xref> theoretic qualitative methodology was used to iteratively generate and assign themes to the study’s literature review articles (i.e., code), until thematic saturation, and an exhaustion of themes, was achieved. The inherent risk in this process is that some themes will be missed, but the assumption is that a general and credible assessment will be produced <xref ref-type="bibr" rid="ridm1841132516">25</xref>. </p>
      <p>The penultimate aim of this process was to produce an integrated, synthesized end-product consisting of brief descriptive accounts of precipitants of burnout, the condition of burnout itself, consequent  safety implications, and corrective interventions as well as a needs assessment on the state of                         effectiveness research. </p>
    </sec>
    <sec id="idm1840177028">
      <title>Findings</title>
      <sec id="idm1840177388">
        <title>Precipitant Factors Related to Psychological Distress / Burn-out</title>
        <p>Nearly ubiquitously, the factors related to Healthcare Practitioner burnout were: high workloads, shift work, excessive work hours, schedule inflexibility, time pressures, communication overload and               interruptions, value incongruence, low control over the job, low safety levels, negative and uncivil and toxic professional relationships and work / social environments, and poor leadership and unsupportive management.<xref ref-type="bibr" rid="ridm1841464676">1</xref><xref ref-type="bibr" rid="ridm1841311956">4</xref><xref ref-type="bibr" rid="ridm1841298748">5</xref><xref ref-type="bibr" rid="ridm1841285036">6</xref><xref ref-type="bibr" rid="ridm1841287556">7</xref><xref ref-type="bibr" rid="ridm1841252428">9</xref><xref ref-type="bibr" rid="ridm1841236620">10</xref><xref ref-type="bibr" rid="ridm1841213036">15</xref><xref ref-type="bibr" rid="ridm1841153180">20</xref> (also see <xref ref-type="bibr" rid="ridm1841308572">3</xref>). Any relations / effects from personal or demographic factors were mixed and slight to none.<xref ref-type="bibr" rid="ridm1841468500">2</xref><xref ref-type="bibr" rid="ridm1841258260">8</xref></p>
        <p>Flynn et al.<xref ref-type="bibr" rid="ridm1841228196">12</xref> found that younger nurses were more prone to burnout, specifically due to not having developed resilience or sufficient situational coping skills. They suggested the counter-intuitive                  findings merited further investigation.<xref ref-type="bibr" rid="ridm1841205476">14</xref>. Basu et al.<xref ref-type="bibr" rid="ridm1841298748">5</xref> observed that workplace stressors were primarily responsible for burnout that resulted in a high “intention to leave”; and noted that with high attrition the workplace situation only got worse for those remaining.(also see <xref ref-type="bibr" rid="ridm1841287556">7</xref>). Koontalay et al. <xref ref-type="bibr" rid="ridm1841158148">19</xref> also found regarding the advent of the COVID-19 pandemic that inadequate preparedness and                     psychological distress (i.e., fear, anxiety, frustration, and stigma) increased substantially as a response to the pandemic, feelings of unpredictability, lack of resources and infrastructure, a perceived unsafe workplace, and lack of competent leadership or leadership’s support, and resulted in high levels of burnout in Healthcare Practitioners. They also noted frontline Healthcare Practitioners, which naturally would include a higher proportion of nurses, suffered more from the precipitants of burnout.<xref ref-type="bibr" rid="ridm1841236620">10</xref><xref ref-type="bibr" rid="ridm1841228196">12</xref><xref ref-type="bibr" rid="ridm1841210660">13</xref><xref ref-type="bibr" rid="ridm1841153180">20</xref></p>
        <p>Sabitova, Hickling, Priebe<xref ref-type="bibr" rid="ridm1841308572">3</xref> found that working conditions—particularly hospital constraints, poor infrastructure, deficient equipment, lack of supplies and medications, especially in the Third World—were sources for poor morale (aka burnout). Additionally, poor financial and non-financial rewards (e.g., career development, advancement, teaching / learning), job security, and excessive workloads also were contributing factors to low morale and a potential for burnout.(also see <xref ref-type="bibr" rid="ridm1841311956">4</xref>) Elliott et al. <xref ref-type="bibr" rid="ridm1841311956">4</xref> found that shift work across an array of health professions was related to poor sleep, exhaustion, and emotional exhaustion—precipitants for burnout.<xref ref-type="bibr" rid="ridm1841153180">20</xref></p>
        <p>Bronkhorst et al.<xref ref-type="bibr" rid="ridm1841464676">1</xref> noted that a “good organizational climate” was significantly related to positive outcomes such as low psychological distress and burnout; logically, the opposite was the case.                     Specifically, they found that collegiality between Healthcare Practitioners, mutual co-worker support, and constant civil communications were the hallmarks of good organizational culture with less risk for distress and burnout.<xref ref-type="bibr" rid="ridm1841308572">3</xref> Flynn et al. <xref ref-type="bibr" rid="ridm1841228196">12</xref>(also see <xref ref-type="bibr" rid="ridm1841311956">4</xref>) observed that increased demands of acute care settings, such as in Emergency Departments or the Intensive Care Units, especially excessive                     communications and interruptions, severely worsened psychological distress and burnout.</p>
        <p>Finally, Li et al.<xref ref-type="bibr" rid="ridm1841258260">8</xref> detected no difference in burnout levels according to Healthcare Practitioner             demographics, experience, geography, and specialties, except in the case where there were slightly lower rates in advanced Health Practitioners and single Health Practitioners.<xref ref-type="bibr" rid="ridm1841468500">2</xref>.</p>
      </sec>
      <sec id="idm1840176164">
        <title>Psychological Distress / Burnout</title>
        <p>Healthcare Practitioner Burnout (e.g., “low morale”, “occupational weariness”) has been depicted as emotional exhaustion, depersonalization, and decreased worker accomplishment deriving from constant and chronic psychological distress.<xref ref-type="bibr" rid="ridm1841468500">2</xref> Burnout has been reported at epidemic proportions among Healthcare Practitioners in the U.S. and worldwide.<xref ref-type="bibr" rid="ridm1841464676">1</xref><xref ref-type="bibr" rid="ridm1841468500">2</xref> Few demographic factors are significant; burnout’s source is rooted in work environment co-factors.<xref ref-type="bibr" rid="ridm1841468500">2</xref> Bronkhorst et al. <xref ref-type="bibr" rid="ridm1841464676">1</xref> observed that is often accompanied by depressive symptoms and general psychological malaise / fugue. Li et al.<xref ref-type="bibr" rid="ridm1841258260">8</xref> characterized workplace burnout in the literature as evidence by emotional exhaustion, low sense of personal accomplishment, low self-esteem, cynicism, low professional efficacy, occupational stress, and poor sleep.<xref ref-type="bibr" rid="ridm1841311956">4</xref>, also see <xref ref-type="bibr" rid="ridm1841153180">20</xref></p>
        <p>Di Ora et al.<xref ref-type="bibr" rid="ridm1841153180">20</xref> noted in the Health Practitioner literature the concept of burnout includes overlap  between symptoms and outcomes. Work disengagement, intention to leave the job, job abandonment, early retirement, medical miscommunication, process errors and subsequent mishaps and accidents are sometimes considered surrogate measures of workplace burnout.<xref ref-type="bibr" rid="ridm1841153180">20</xref> They also found a high degree of Health Practitioner value incongruence with their jobs and incivility were signs of burnout. Worse, Elliott et al.<xref ref-type="bibr" rid="ridm1841311956">4</xref> found that burnout includes negative attitudes towards patient care and safety.</p>
      </sec>
      <sec id="idm1840176884">
        <title>Safety Implications</title>
        <p>Undeniably, Health Practitioner burnout unchecked has detrimental medical care quality and safety implications for patients, co-workers, and the Health Practitioners themselves; but the nature and the extent of that relationship is sketchy and questionable.<xref ref-type="bibr" rid="ridm1841298748">5</xref><xref ref-type="bibr" rid="ridm1841258260">8</xref><xref ref-type="bibr" rid="ridm1841252428">9</xref><xref ref-type="bibr" rid="ridm1841228196">12</xref><xref ref-type="bibr" rid="ridm1841468500">2</xref> According to Hall et al.<xref ref-type="bibr" rid="ridm1841252428">9</xref> higher Health Practitioner burnout significantly results in more medical errors. Research               unequivocally has shown that Healthcare Practitioner burn-out related inattention increases the risk for medication errors, infection precaution non-observance, failure to recognize life threatening signs /symptoms and delayed reaction, missed patient falls, needle sticks, and other critical safety issues and risky harm scenarios, including mortality.<xref ref-type="bibr" rid="ridm1841468500">2</xref><xref ref-type="bibr" rid="ridm1841311956">4</xref><xref ref-type="bibr" rid="ridm1841258260">8</xref><xref ref-type="bibr" rid="ridm1841153180">20</xref> These burnout situations were not related to              personal or demographic factors. <xref ref-type="bibr" rid="ridm1841252428">9</xref> Hall et al.<xref ref-type="bibr" rid="ridm1841252428">9</xref> found a direct and consistent relationship between workload (i.e., substantial numbers of patients), burnout, poor quality of patient care, and a high               number of medical mistakes, which were actually underreported due to the high workload.</p>
        <p>Health Practitioner burnout by whatever means is significantly related to poor patient care and safety, though there may be more “near misses” than actual adverse events.<xref ref-type="bibr" rid="ridm1841252428">9</xref> Flynn et al. <xref ref-type="bibr" rid="ridm1841228196">12</xref> found that Health Practitioner burn-out, when organization-wide, can contribute to an unsafer organizational            climate creating a detachment from workload, incomplete safety procedures (especially infection               control), and decreased patient engagement. Nevertheless, that link between burnout and safety is              tenuous at best due to under-or-over-reporting: under reporting seemed the result of punitive measures for reporting; whereas, over-reporting seemed to be caused by rewarding or encouraging reporting.<xref ref-type="bibr" rid="ridm1841176572">17</xref> Ironically, Flynn et al. and Hall et al <xref ref-type="bibr" rid="ridm1841258260">8</xref><xref ref-type="bibr" rid="ridm1841228196">12</xref> observed that the very act of reporting errors also can             exacerbate burnout in Healthcare Practitioners. These findings have led some to conclude there is no direct correlative link between Health Practitioner burn-out and safety.<xref ref-type="bibr" rid="ridm1841258260">8</xref><xref ref-type="bibr" rid="ridm1841228196">12</xref><xref ref-type="bibr" rid="ridm1841176572">17</xref> The ambiguous nature and link of that supposed relationship warrants definitive prospective research.<xref ref-type="bibr" rid="ridm1841468500">2</xref><xref ref-type="bibr" rid="ridm1841258260">8</xref><xref ref-type="bibr" rid="ridm1841228196">12</xref></p>
        <p>Another interpretation of Jun et al.’s<xref ref-type="bibr" rid="ridm1841468500">2</xref> and Flynn et al.’s<xref ref-type="bibr" rid="ridm1841228196">12</xref> mixed findings regarding major                surrogate safety measures of burnout, specifically, near misses and intention  to leave / leaving, suggest that Healthcare Practitioners are opting out of work situations conducive to poor mental health and burnout in the interest of patient care and safety. That is, ironically, intention to leave, leaving the job, and job abandonment actually may be a tribute to Healthcare Practitioners’ professionalism—if they are suffering burnout and prone to safety breaches—they would rather leave than risk the health and well-being of their patients and colleagues. This is worthy of further investigation. </p>
        <p>Along with the permanent psychological harm of burnout to Healthcare Practitioners, Whitcombe, Cooper, and Palmer <xref ref-type="bibr" rid="ridm1841213036">15</xref> identified other physical hazards resulting from burnout. such as                           cross-infection, manual hand injuries, slip-trip-and-falls, soft-tissue back injuries, chemical-substance-medication exposure, solo work and violent or abusive patients (especially for mental health workers<xref ref-type="bibr" rid="ridm1841285036">6</xref>), and the most prominent dangerous medical work-related injury, namely, non-attentive needle sticks.<xref ref-type="bibr" rid="ridm1841464676">1</xref><xref ref-type="bibr" rid="ridm1841213036">15</xref> In sum, Healthcare Practitioner burnout adversely affects Health Practitioners, patients, health organizations, and society worsening safety, quality of care, and Health Practitioners’                       commitment.<xref ref-type="bibr" rid="ridm1841468500">2</xref></p>
        <p>Additionally, burnout was cited consistently as a cause for Health Practitioners intent to leave their jobs, leave, or abandon their jobs, and seek early retirement.<xref ref-type="bibr" rid="ridm1841468500">2</xref><xref ref-type="bibr" rid="ridm1841287556">7</xref><xref ref-type="bibr" rid="ridm1841228196">12</xref><xref ref-type="bibr" rid="ridm1841213036">15</xref><xref ref-type="bibr" rid="ridm1841153180">20</xref> This increases recruitment and training costs to health organizations, further increases workloads and risk of burnout for those remaining, and reduces morale and quality of patient care. Overall, the financial loss to the entire healthcare system is staggering.<xref ref-type="bibr" rid="ridm1841468500">2</xref></p>
      </sec>
      <sec id="idm1840158756">
        <title>Intervention Programs (“the Fixes”)</title>
      </sec>
      <sec id="idm1840160556">
        <title>Organizational Level Interventions</title>
        <p>In a perfect world, ideally workloads would be lowered, organization / worker values forged                   congruently , consistent civility would be maintained in the workplace, flex schedules would prevail, shift work would be abolished, time pressures would be dissipated, work would be inherently                   interesting and rewarding, and Health Care Practitioners would be supported 100% by informed,                 stellar, altruistic leadership, while burnout levels would bottom out. Presumably, burnout-related safety hazards and harms would then just disappear. As improbable as that seems, research suggests that             interventions that address , fix, or even just tweak one or more fundamental and “tangible”                 organizational aspects precipitating burnout, are very effective in decreasing burnout.<xref ref-type="bibr" rid="ridm1841298748">5</xref> However, they also may be unrealistic, impractical, and most likely unaffordable.<xref ref-type="bibr" rid="ridm1841308572">3</xref><xref ref-type="bibr" rid="ridm1841298748">5</xref> For example, research shows that Health Practitioner psychological distress, a precursor to burnout, can be greatly reduced simply by improving civility and communication in the workplace or scheduling better or reducing workloads even a little.<xref ref-type="bibr" rid="ridm1841146988">21</xref></p>
      </sec>
      <sec id="idm1840159044">
        <title>Psychological-Level Interventions</title>
        <p>Most psychologistic interventions designed to help fight Health Practitioner burnout fall under the  theoretical rubric of Cognitive Behavioral Therapy (CBT), which is designed to replace negative thought patterns and behaviors contributing to psychological distress and burnout, rather than change            workplace conditions.<xref ref-type="bibr" rid="ridm1841258260">8</xref> The two most prominent components are Mindfulness and Resilience. </p>
      </sec>
      <sec id="idm1840159116">
        <title>Mindfulness</title>
        <p>Mindfulness programs train Health Practitioners in groups over a period of time with the aim of                  increasing their ability to contemplatively pay attention and be “in the present moment” non-judgmentally to facilitate relaxation and calm the body and mind.<xref ref-type="bibr" rid="ridm1841236620">10</xref> Research has shown that these programs are effective in reducing Health Practitioners’ stress levels and improving their attention and concentration to minimize workplace safety mishaps.<xref ref-type="bibr" rid="ridm1841236620">10</xref></p>
      </sec>
      <sec id="idm1840160052">
        <title>Resilience</title>
        <p>These programs aim to improve Health Practitioners’ equilibrium under stress by training them to keep a sense of control and continue to forge onward positively despite adversity and emotional distress.<xref ref-type="bibr" rid="ridm1841176572">17</xref> Early research reported that web-based resilience burnout prevention / intervention programs significantly improved resilience to psychological distress / burnout, improved well-being, work engagement, and improved overall emotions on par with didactic in-person ones; however, these claims have since been hedged substantially.<xref ref-type="bibr" rid="ridm1841210804">16</xref><xref ref-type="bibr" rid="ridm1841176572">17</xref><xref ref-type="bibr" rid="ridm1841158148">19</xref> However, by reducing burnout psychologically, these programs may improve the safety of the health organization, while preserving the mental health and well-being of staff. also see, <xref ref-type="bibr" rid="ridm1841169804">18</xref>. Regarding the value of on-line resilience training in general, Henshall et al. <xref ref-type="bibr" rid="ridm1841176572">17</xref> found its benefits to be convenience and accessibility, though the downside was that it failed to capture support in the workplace that seems crucial to warding-off burnout. This suggests that both online and in-person burnout programs have benefits depending on the target audience and situation; a                  multi-modality approach is probably optimal.</p>
        <p>Regardless of theoretical underscoring of psychological interventions addressing burnout, what appears to work are interventions incorporating participative leadership, an organizational culture facilitating interdisciplinary teamwork with civility, and feedback that emphasizes the positive aspects of the work in a safe, supportive environment.<xref ref-type="bibr" rid="ridm1841210804">16</xref></p>
      </sec>
      <sec id="idm1840159692">
        <title>Culture of Safety</title>
        <p>An intervention that has shown great promise in terms of addressing burn-out and related safety                 mishaps is the eponymous implementation of a Culture of Safety.<xref ref-type="bibr" rid="ridm1841235972">11</xref> Though varied and complex, a major feature of it is advancing the quality of healthcare and reducing patient and worker harm through focusing and learning from events / incidents and translating that into best practices and policy                   involving staff support in the learning process.<xref ref-type="bibr" rid="ridm1841235972">11</xref> Research has shown that a functional culture can be replaced with a socially supportive one through teamwork aimed at improving safety and                           communication; this is psychologically beneficial to Healthcare Practitioners and crucial to reducing / eliminating psychological distress and burnout.<xref ref-type="bibr" rid="ridm1841235972">11</xref><xref ref-type="bibr" rid="ridm1841464676">1</xref>  Since health organizations managers are           directly involved in promoting safety and caring for workers, worker perception and attitudes              improves.<xref ref-type="bibr" rid="ridm1841235972">11</xref> In a Culture of Safety, frontline workers are also considered leaders too, thus, their             feelings over control of their work improves, and their self-efficacy improves—reducing psychological stress and burnout, while improving job satisfaction.<xref ref-type="bibr" rid="ridm1841235972">11</xref></p>
        <p>Overall, research has shown that implementing a Culture of Safety results in dramatic drops in Health Practitioner attrition and improvements in attitudes; there are improvements in working conditions, since communication and collaboration improves as Healthcare Practitioners are involved in planning of safety and even staffing, which have been sore points resulting in burnout.<xref ref-type="bibr" rid="ridm1841235972">11</xref><xref ref-type="bibr" rid="ridm1841468500">2</xref><xref ref-type="bibr" rid="ridm1841311956">4</xref><xref ref-type="bibr" rid="ridm1841285036">6</xref><xref ref-type="bibr" rid="ridm1841258260">8</xref><xref ref-type="bibr" rid="ridm1841252428">9</xref><xref ref-type="bibr" rid="ridm1841228196">12</xref> Studies have shown that when frontline Healthcare Practitioners felt management supported them and were concerned for their well-being, there was a reduction of psychological stress, low morale, and burnout, and quality of patient care increased—by-products of a Culture of Safety. <xref ref-type="bibr" rid="ridm1841464676">1</xref><xref ref-type="bibr" rid="ridm1841287556">7</xref><xref ref-type="bibr" rid="ridm1841235972">11</xref><xref ref-type="bibr" rid="ridm1841228196">12</xref>. Most importantly, a Culture of Safety strives for value congruence between the organization and the Healthcare Practitioner, ultimately reducing Healthcare Practitioner psychological stress and burnout.</p>
        <p>Note: In the literature, there was mention of a burn-out reduction intervention for a hospital Emergency Department consisting of aromatherapy combined with massage sessions over a 12-week period that resulted in a slight reduction in short term anxiety levels. Also, the final verdict on Mentorship                  programs is that they do not affect workplace psychological distress and burnout.<xref ref-type="bibr" rid="ridm1841298748">5</xref></p>
      </sec>
    </sec>
    <sec id="idm1840157028" sec-type="discussion">
      <title>Discussion / Conclusion</title>
      <p>This article provided a firmer grasp on the current state of science and best practices regarding Healthcare Practitioner burnout precipitants, actual burnout, safety implications, and corrective                  interventions through a theoretical grounded literature review of literature reviews on an extensively researched subject. Healthcare Practitioners play a fundamental role in quality of care and safety and are the foundation of healthcare organizations—hence, management / leadership should be concerned for their wellbeing. Poor healthcare work environments create psychological distress and burnout in Healthcare Practitioners, specifically, environments characterized by excessive workloads, shift work, value incongruence, low control over the job, inordinate time pressures, communications overload, incessant interruptions, negative / uncivil professional relationships, a toxic social climate, and                  uninvolved, uncaring, unsympathetic, and unsupportive management. The mental condition of burnout renders the Health Practitioners prone to making inattentive medical errors that place patients,                         co-workers and even themselves in jeopardy and harm. Fundamental Organizational fixes addressing the precipitants of Health Practitioner burnout, though very powerful, can be impractical and                       unaffordable. There are also impactful Psychological Intervention programs aimed at addressing and ameliorating the psychological distress and burnout itself through: Cognitive Behavioral Mindfulness and Resilience Training. Also, in a Culture of Safety there is a promising powerful multi-faceted and complicated intervention. Singularly, in combination, or with Fundamental Organizational fixes, they have been shown to be extremely powerful remedies in reducing Health Practitioner psychological  distress and burnout.</p>
      <p>What seems to make these Psychological Interventions work are the aspects they have in common,  specifically: they are training and learning programs that emphasize teamwork and common purpose, management / leadership’s involvement and support / concern / caring, workers assuming a degree of control over their jobs, related job condition improvement, cohesive positive interdisciplinary                communications, mutual professional respect and civility, and overall consciousness raising in terms of psychological distress and burnout avoidance. </p>
      <p>There are vetted programs available to help Health Practitioners and health organizations improve workplace mental health in the interest of quality patient care and safety as well as worker well-being and safety. </p>
      <sec id="idm1840158108">
        <title>Limitations</title>
        <p>There was a discordance between the methodology of grounded iterative thematic enumeration of all variants and the aim of the study to produce a purer synthesis of already synthesized materials.<xref ref-type="bibr" rid="ridm1841137340">24</xref><xref ref-type="bibr" rid="ridm1841132516">25</xref><xref ref-type="bibr" rid="ridm1841130284">26</xref> Nevertheless, the method ensured a comprehensive identification, organization, and solid descriptive accounting of what is currently known, and the state of the science and best practices regarding the study’s subject matter. Another inherent limitation of the grounded methodology is the possibility of some extreme obscure variant escaping detection or being overlooked.<xref ref-type="bibr" rid="ridm1841132516">25</xref><xref ref-type="bibr" rid="ridm1841130284">26</xref> Nevertheless, the final product represented a staggering number of original peer-reviewed research study reports and probably nearly exhausted variants. Although this study only included peer-reviewed articles, missing the “grey” literature reviews (e.g., in-house program evaluations or trade journal articles), there was a degree  quality control assurance regarding findings in terms of scientific merit. Another methodological                 limitation was that, as the study was a descriptive / qualitative inventory and not quantitative, findings were given equal weight; so there could be no effect size comparisons.<xref ref-type="bibr" rid="ridm1841205476">14</xref>. Future research should consider meta-analysis. Similarly, there was no formal estimate of the quality of research articles              included. Nevertheless, 16 of the 21 studies (77%) specifically adhered to PRISMA guidelines ensuring literature review quality. </p>
        <p>It would be expected that restricting the key words for search articles would exclude journals using synonyms or foreign journals using different words; but this did not appear to be the case, as there was diversity of different terms and different nations from which articles came. Though most articles did come from the Western world, they represented a variety of Western nations, and even a Third World comparison nation was included in one of the journal articles. Of course, there is the issue to limiting the reviewed articles’ language to either English or translated English. Future research should similarly explore non-English speaking literature reviews as a comparison. Furthermore, treating Health                 Practitioners in the aggregate created a lack of heterogeneity, making generalizability to sub-groups difficult, but not impossible. This is another area that could benefit from future research. However, recent research reports indicate that all Health Practitioner sub-groups are more or less similarly               affected by burnout and are at risk for making medical mistakes, and could benefit from programmatic interventions. <xref ref-type="bibr" rid="ridm1841464676">1</xref><xref ref-type="bibr" rid="ridm1841311956">4</xref><xref ref-type="bibr" rid="ridm1841298748">5</xref><xref ref-type="bibr" rid="ridm1841285036">6</xref><xref ref-type="bibr" rid="ridm1841252428">9</xref><xref ref-type="bibr" rid="ridm1841235972">11</xref><xref ref-type="bibr" rid="ridm1841169804">18</xref></p>
      </sec>
      <sec id="idm1840158180">
        <title>Recommendations / Future Research</title>
        <p>Probably the most profound recommendation derived from this work is that, before a healthcare               workplace plunges in a downward spiral and that devolves into an overwhelming morass of Health Practitioner burnout and related problems, leadership / management must act quickly and follow the scientific research based best practice blueprint contained in this research report and reach for that near “200 proof.”* Preventive intervention is generally less expensive than curative remediation.</p>
        <p>Besides gaps in knowledge already identified in this review, other similar systematic literature reviews should be conducted on other high stress occupations where safety is a premium as a comparison to verify the universality of this study’s findings. For the same reason, cross-national literature review studies of literature reviews should be conducted too. </p>
        <p>*Note: “Moonshiners” commonly refer to double-distilled near 200 proof spirits in common parlance as “White Lightening.” <xref ref-type="bibr" rid="ridm1841127548">27</xref></p>
      </sec>
    </sec>
    <sec id="idm1840156812">
      <title>Declarations</title>
      <sec id="idm1840157532">
        <title>Ethical approval and consent to participate</title>
        <p>Non-applicable, this was a commentary accompanied by a review of supporting open-source documents.</p>
      </sec>
      <sec id="idm1840155084">
        <title>Consent for Publication</title>
        <p>Yes.</p>
      </sec>
      <sec id="idm1840155012">
        <title>Availability of data and materials</title>
        <p>Yes, publications and sources are available on-line or provided or by author upon request.</p>
      </sec>
      <sec id="idm1840154292">
        <title>Competing interests</title>
        <p>None declared.</p>
      </sec>
      <sec id="idm1840154148">
        <title>Funding</title>
        <p>The author gratefully acknowledges UT-MDACC for in-kind support.</p>
      </sec>
      <sec id="idm1840155588">
        <title>Authors’ Contribution</title>
        <p>Non-applicable, there is one sole Author.</p>
        <p>Acknowledgements</p>
        <p>The Author wishes to gratefully acknowledge in-kind support of the Department of Lymphoma and Myeloma, UT-MD Anderson Cancer Center, Houston, TX. in the preparation of this manuscript. Also, the author thanks Mr. Jasper Olsem for the concept and his encouragement in pursuing the subject matter. The author also expresses appreciation Ms. Aileen “Acey” Cho freelance-copy editor for proofing and copyediting drafts. The opinions expressed are solely those of the Author. Reprints and correspondence should be addressed to the author at <ext-link xlink:href="mailto:rjjohnson@mdanderson.org" ext-link-type="uri">rjjohnson@mdanderson.org</ext-link> or, UT-MDACC, Dept. of Lymphoma / Myeloma, Unit 429, 1515 Holcombe, Houston, Texas, 77030-400, U.S.A.. (832-372-3511)</p>
      </sec>
    </sec>
  </body>
  <back>
    <ref-list>
      <ref id="ridm1841464676">
        <label>1.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Bronkhorst</surname>
            <given-names>B</given-names>
          </name>
          <name>
            <surname>Tummers</surname>
            <given-names>L</given-names>
          </name>
          <name>
            <surname>Steijn</surname>
            <given-names>B</given-names>
          </name>
          <name>
            <surname>Vijverberg</surname>
            <given-names>D</given-names>
          </name>
          <article-title>Organizational climate and employee mental health outcomes: A systematic review of studies in health care organizations.Health Care Manage Rev.40(3):</article-title>
          <date>
            <year>2015</year>
          </date>
          <fpage>254</fpage>
          <lpage>71</lpage>
          <pub-id pub-id-type="doi">10.1097/HMR.0000000000000026</pub-id>
          <pub-id pub-id-type="pmid">24901297.https://journals.lww.com/hcmrjournal/abstract/2015/07000organizational_climate_and_employee_mental_health.7.aspx</pub-id>
        </mixed-citation>
      </ref>
      <ref id="ridm1841468500">
        <label>2.</label>
        <mixed-citation xlink:type="simple" publication-type="book"><name><surname>Jun</surname><given-names>J</given-names></name><name><surname>Ojemeni</surname><given-names>M M</given-names></name><name><surname>Kalamani</surname><given-names>R</given-names></name><name><surname>Tong</surname><given-names>J</given-names></name><name><surname>Crecelius</surname><given-names>M L</given-names></name><article-title>Relationship between nurse burnout, patient and organizational outcomes:</article-title><date><year>2021</year></date><chapter-title>Systematic review.Int J Nurs Stud.2021; 119: 103933. doi: 10.1016/j.ijnurstu.2021.103933. Epub</chapter-title>
PMID: 33901940.https://www.sciencedirect.com/science/article/abs/pii/S0020748921000742?via%3Dihub



<pub-id pub-id-type="doi">10.1016/j.ijnurstu.2021.103933</pub-id><pub-id pub-id-type="pmid">33901940.https://www.sciencedirect.com/science/article/abs/pii/S0020748921000742?via%3Dihub</pub-id></mixed-citation>
      </ref>
      <ref id="ridm1841308572">
        <label>3.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Sabitova</surname>
            <given-names>A</given-names>
          </name>
          <name>
            <surname>Hickling</surname>
            <given-names>L M</given-names>
          </name>
          <name>
            <surname>Priebe</surname>
            <given-names>S Job</given-names>
          </name>
          <article-title>morale: a scoping review of how the concept developed and is used in healthcare research.BMC Public Health</article-title>
          <date>
            <year>2020</year>
          </date>
          <volume>20</volume>
          <issue>1</issue>
          <fpage>1166</fpage>
          <lpage>10</lpage>
          <pub-id pub-id-type="doi">10.1186/s12889-020-09256-6</pub-id>
          <pub-id pub-id-type="pmid">32711485.https://pmc.ncbi.nlm.nih.gov/articles/PMC7382865/</pub-id>
        </mixed-citation>
      </ref>
      <ref id="ridm1841311956">
        <label>4.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Elliott</surname>
            <given-names>J</given-names>
          </name>
          <name>
            <surname>Hodges</surname>
            <given-names>C</given-names>
          </name>
          <name>
            <surname>Boots</surname>
            <given-names>M</given-names>
          </name>
          <name>
            <surname>Pattinson</surname>
            <given-names>R</given-names>
          </name>
          <name>
            <surname>Gillen</surname>
            <given-names>E</given-names>
          </name>
          <name>
            <surname>Whybrow</surname>
            <given-names>D</given-names>
          </name>
          <name>
            <surname>Bundy</surname>
            <given-names>C</given-names>
          </name>
          <article-title>Mixed shift rotations, sleep, burnout and well-being in professions similar to radiographers: A systematic review.Radiography (Lond).2024;30(4): 1194-1200. doi: 10.1016/j.radi.2024.05.016. Epub</article-title>
          <date>
            <year>2024</year>
          </date>
          <fpage>38901073</fpage>
          <lpage>10</lpage>
          <pub-id pub-id-type="doi">10.1016/j.radi.2024.05.016</pub-id>
          <pub-id pub-id-type="pmid">38901073</pub-id>
        </mixed-citation>
      </ref>
      <ref id="ridm1841298748">
        <label>5.</label>
        <mixed-citation xlink:type="simple" publication-type="journal"><name><surname>Basu</surname><given-names>S</given-names></name><name><surname>Qayyum</surname><given-names>H</given-names></name><name><surname>Mason</surname><given-names>S</given-names></name><article-title>Occupational stress in the ED: a systematic literature review.Emerg</article-title><date><year>2017</year></date><source>Med</source><volume>34</volume><issue>7</issue><fpage>441</fpage><lpage>447</lpage>
PMID: 27729392.https://emj.bmj.com/content/34/7/441.long



<pub-id pub-id-type="doi">10.1136/emermed-2016-205827</pub-id><pub-id pub-id-type="pmid">27729392.https://emj.bmj.com/content/34/7/441.long</pub-id></mixed-citation>
      </ref>
      <ref id="ridm1841285036">
        <label>6.</label>
        <mixed-citation xlink:type="simple" publication-type="journal"><name><surname>Johnson</surname><given-names>J</given-names></name><name><surname>Hall</surname><given-names>L H</given-names></name><name><surname>Berzins</surname><given-names>K</given-names></name><name><surname>Baker</surname><given-names>J</given-names></name><name><surname>Melling</surname><given-names>K</given-names></name><name><surname>Thompson</surname><given-names>C</given-names></name><article-title>Mental healthcare staff well-being and burnout: A narrative review of trends, causes, implications, and recommendations for future interventions.Int</article-title><date><year>2018</year></date><source>J Mental Hlth</source><volume>27</volume><issue>1</issue>
PMID: 29243348.https://onlinelibrary.wiley.com/doi/10.1111/inm.12416



<pub-id pub-id-type="doi">10.1111/inm.12416</pub-id><pub-id pub-id-type="pmid">29243348.https://onlinelibrary.wiley.com/doi/10.1111/inm.12416</pub-id></mixed-citation>
      </ref>
      <ref id="ridm1841287556">
        <label>7.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Świtalski</surname>
            <given-names>J</given-names>
          </name>
          <name>
            <surname>Wnuk</surname>
            <given-names>K</given-names>
          </name>
          <name>
            <surname>Tatara</surname>
            <given-names>T</given-names>
          </name>
          <name>
            <surname>Miazga</surname>
            <given-names>W</given-names>
          </name>
          <name>
            <surname>Wiśniewska</surname>
            <given-names>E</given-names>
          </name>
          <name>
            <surname>Banaś</surname>
            <given-names>T</given-names>
          </name>
          <name>
            <surname>Partyka</surname>
            <given-names>O</given-names>
          </name>
          <name>
            <surname>Karakiewicz-Krawczyk</surname>
            <given-names>K</given-names>
          </name>
          <name>
            <surname>Jurczak</surname>
            <given-names>J</given-names>
          </name>
          <name>
            <surname>Kaczmarski</surname>
            <given-names>M</given-names>
          </name>
          <name>
            <surname>Dykowska</surname>
            <given-names>G</given-names>
          </name>
          <name>
            <surname>Czerw</surname>
            <given-names>A</given-names>
          </name>
          <name>
            <surname>Cipora</surname>
            <given-names>E</given-names>
          </name>
          <article-title>Interventions to Increase Patient Safety in Long-Term Care Facilities-Umbrella Review.Int J Environ Res Public Health</article-title>
          <date>
            <year>2022</year>
          </date>
          <volume>19</volume>
          <issue>22</issue>
          <fpage>15354</fpage>
          <lpage>10</lpage>
          <pub-id pub-id-type="doi">10.3390/ijerph192215354</pub-id>
          <pub-id pub-id-type="pmid">36430073.https://pmc.ncbi.nlm.nih.gov/articles/PMC9691014/</pub-id>
        </mixed-citation>
      </ref>
      <ref id="ridm1841258260">
        <label>8.</label>
        <mixed-citation xlink:type="simple" publication-type="book">
          <name>
            <surname>Li</surname>
            <given-names>L N</given-names>
          </name>
          <name>
            <surname>Yang</surname>
            <given-names>P</given-names>
          </name>
          <name>
            <surname>Singer</surname>
            <given-names>S J</given-names>
          </name>
          <name>
            <surname>Pfeffer</surname>
            <given-names>J</given-names>
          </name>
          <name>
            <surname>Mathur</surname>
            <given-names>M B</given-names>
          </name>
          <name>
            <surname>Shanafelt</surname>
            <given-names>T</given-names>
          </name>
          <date>
            <year>2024</year>
          </date>
          <chapter-title>Nurse Burnout and Patient Safety, Satisfaction, and Quality of Care: A Systematic Review and Meta-Analysis.JAMA Network Open.7(11):e2443059. doi: 10.1001/jamanetworkopen.2024.43059. PMID: 39499515.https://pmc.ncbi.nlm.nih.gov/articles/PMC11539016/</chapter-title>
          <pub-id pub-id-type="doi">10.1001/jamanetworkopen.2024.43059</pub-id>
          <pub-id pub-id-type="pmid">39499515.https://pmc.ncbi.nlm.nih.gov/articles/PMC11539016/</pub-id>
        </mixed-citation>
      </ref>
      <ref id="ridm1841252428">
        <label>9.</label>
        <mixed-citation xlink:type="simple" publication-type="journal"><name><surname>Hall</surname><given-names>L H</given-names></name><name><surname>Johnson</surname><given-names>J</given-names></name><name><surname>Watt</surname><given-names>I</given-names></name><name><surname>Tsipa</surname><given-names>A</given-names></name><name><surname>O'Connor</surname><given-names>D B</given-names></name><article-title>Healthcare Staff Wellbeing, Burnout, and Patient Safety: A Systematic Review. PLoS One</article-title><date><year>2016</year></date><volume>11</volume><issue>7</issue><fpage>10</fpage><lpage>1371</lpage>
PMID: 27391946https://pmc.ncbi.nlm.nih.gov/articles/PMC4938539/



<pub-id pub-id-type="doi">10.1371/journal.pone.0159015</pub-id><pub-id pub-id-type="pmid">27391946https://pmc.ncbi.nlm.nih.gov/articles/PMC4938539/</pub-id></mixed-citation>
      </ref>
      <ref id="ridm1841236620">
        <label>10.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Botha</surname>
            <given-names>E</given-names>
          </name>
          <name>
            <surname>Gwin</surname>
            <given-names>T</given-names>
          </name>
          <name>
            <surname>Purpora</surname>
            <given-names>C</given-names>
          </name>
          <article-title>The effectiveness of mindfulness-based programs in reducing stress experienced by nurses in adult hospital settings: a systematic review of quantitative evidence protocol.JBI Database System Rev Implement Rep</article-title>
          <date>
            <year>2015</year>
          </date>
          <volume>13</volume>
          <issue>10</issue>
          <fpage>21</fpage>
          <lpage>9</lpage>
          <pub-id pub-id-type="doi">10.11124/jbisrir-2015-2380</pub-id>
          <pub-id pub-id-type="pmid">26571279https://pubmed.ncbi.nlm.nih.gov/26571279/</pub-id>
        </mixed-citation>
      </ref>
      <ref id="ridm1841235972">
        <label>11.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Finn</surname>
            <given-names>M</given-names>
          </name>
          <name>
            <surname>Walsh</surname>
            <given-names>A</given-names>
          </name>
          <name>
            <surname>Rafter</surname>
            <given-names>N</given-names>
          </name>
          <name>
            <surname>Mellon</surname>
            <given-names>L</given-names>
          </name>
          <name>
            <surname>Chong</surname>
            <given-names>H Y</given-names>
          </name>
          <name>
            <surname>Naji</surname>
            <given-names>A</given-names>
          </name>
          <name>
            <surname>O'Brien</surname>
            <given-names>N</given-names>
          </name>
          <name>
            <surname>Williams</surname>
            <given-names>D J</given-names>
          </name>
          <name>
            <surname>McCarthy</surname>
            <given-names>S E</given-names>
          </name>
          <article-title>Effect of interventions to improve safety culture on healthcare workers in hospital settings: a systematic review of the international literature.BMJ Open Qual</article-title>
          <date>
            <year>2024</year>
          </date>
          <volume>13</volume>
          <issue>2</issue>
          <fpage>10</fpage>
          <lpage>1136</lpage>
          <pub-id pub-id-type="doi">10.1136/bmjoq-2023-002506</pub-id>
          <pub-id pub-id-type="pmid">38719514.https://pmc.ncbi.nlm.nih.gov/articles/PMC11086522/</pub-id>
        </mixed-citation>
      </ref>
      <ref id="ridm1841228196">
        <label>12.</label>
        <mixed-citation xlink:type="simple" publication-type="book">
          <name>
            <surname>Flynn</surname>
            <given-names>C</given-names>
          </name>
          <name>
            <surname>Watson</surname>
            <given-names>C</given-names>
          </name>
          <name>
            <surname>Patton</surname>
            <given-names>D</given-names>
          </name>
          <name>
            <surname>O'Connor</surname>
            <given-names>T</given-names>
          </name>
          <article-title>The impact of burnout on paediatric nurses' attitudes about patient safety in the acute hospital setting: A systematic review.J</article-title>
          <date>
            <year>2024</year>
          </date>
          <chapter-title>Pediatr Nurs.2024;78: 82-89. doi: 10.1016/j.pedn.2024.06.023. Epub</chapter-title>
          <volume>16</volume>
          <fpage>39019737</fpage>
          <lpage>0882</lpage>
          <pub-id pub-id-type="doi">10.1016/j.pedn.2024.06.023</pub-id>
          <pub-id pub-id-type="pmid">39019737.https://linkinghub.elsevier.com/retrieve/pii/S0882-5963(24)00251-3</pub-id>
        </mixed-citation>
      </ref>
      <ref id="ridm1841210660">
        <label>13.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Hill</surname>
            <given-names>B</given-names>
          </name>
          <article-title>Do nurse staffing levels affect patient mortality in acute secondary care?</article-title>
          <date>
            <year>2017</year>
          </date>
          <source>Br J</source>
          <volume>26</volume>
          <issue>12</issue>
          <fpage>698</fpage>
          <lpage>704</lpage>
          <pub-id pub-id-type="doi">10.12968/bjon.2017.26.12.698</pub-id>
          <pub-id pub-id-type="pmid">28640732.https://www.magonlinelibrary.com/doi/abs/10.12968/bjon.2017.26.12.698</pub-id>
        </mixed-citation>
      </ref>
      <ref id="ridm1841205476">
        <label>14.</label>
        <mixed-citation xlink:type="simple" publication-type="book"><name><surname>Stevanin</surname><given-names>S</given-names></name><name><surname>Palese</surname><given-names>A</given-names></name><name><surname>Bressan</surname><given-names>V</given-names></name><name><surname>Vehviläinen-Julkunen</surname><given-names>K</given-names></name><name><surname>Kvist</surname><given-names>T</given-names></name><article-title>Workplace-related generational characteristics of nurses: A mixed-method systematic review.J</article-title><date><year>2018</year></date><chapter-title>Adv Nurs.2018 Jun;74(6): 1245-1263. doi: 10.1111/jan.13538. Epub</chapter-title>
PMID: 29424038.https://onlinelibrary.wiley.com/doi/10.1111/jan.13538



<pub-id pub-id-type="doi">10.1111/jan.13538</pub-id><pub-id pub-id-type="pmid">29424038.https://onlinelibrary.wiley.com/doi/10.1111/jan.13538</pub-id></mixed-citation>
      </ref>
      <ref id="ridm1841213036">
        <label>15.</label>
        <mixed-citation xlink:type="simple" publication-type="journal"><name><surname>Whitcombe</surname><given-names>A</given-names></name><name><surname>Cooper</surname><given-names>K</given-names></name><name><surname>Palmer</surname><given-names>E</given-names></name><article-title>The relationship between organizational culture and the health and wellbeing of hospital nurses worldwide: a mixed methods systematic review protocol.JBI Database System Rev Implement Rep.14(6):</article-title><date><year>2016</year></date><fpage>103</fpage><lpage>16</lpage>
PMID: 27532655.https://journals.lww.com/jbisrir/fulltext/2016/06000 the_relationship_between_organizational_culture.13.aspx


<pub-id pub-id-type="doi">10.11124/JBISRIR-2016-002650</pub-id><pub-id pub-id-type="pmid">27532655.https://journals.lww.com/jbisrir/fulltext/2016/06000</pub-id></mixed-citation>
      </ref>
      <ref id="ridm1841210804">
        <label>16.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Härkänen</surname>
            <given-names>M</given-names>
          </name>
          <name>
            <surname>Pineda</surname>
            <given-names>A L</given-names>
          </name>
          <name>
            <surname>Tella</surname>
            <given-names>S</given-names>
          </name>
          <name>
            <surname>Mahat</surname>
            <given-names>S</given-names>
          </name>
          <name>
            <surname>Panella</surname>
            <given-names>M</given-names>
          </name>
          <name>
            <surname>Ratti</surname>
            <given-names>M</given-names>
          </name>
          <name>
            <surname>Vanhaecht</surname>
            <given-names>K</given-names>
          </name>
          <name>
            <surname>Strametz</surname>
            <given-names>R</given-names>
          </name>
          <name>
            <surname>Carrillo</surname>
            <given-names>I</given-names>
          </name>
          <name>
            <surname>Rafferty</surname>
            <given-names>A M</given-names>
          </name>
          <name>
            <surname>Wu</surname>
            <given-names>A W</given-names>
          </name>
          <name>
            <surname>Anttila</surname>
            <given-names>V J</given-names>
          </name>
          <name>
            <surname>Mira</surname>
            <given-names>J J</given-names>
          </name>
          <article-title>The impact of emotional support on healthcare workers and students coping with COVID-19, and other SARS-CoV pandemics - a mixed-methods systematic review.BMC Health Serv Res.23(1):</article-title>
          <date>
            <year>2023</year>
          </date>
          <volume>751</volume>
          <fpage>10</fpage>
          <lpage>1186</lpage>
          <pub-id pub-id-type="doi">10.1186/s12913-023-09744-6</pub-id>
          <pub-id pub-id-type="pmid">37443003.https://pmc.ncbi.nlm.nih.gov/articles/PMC10339499/</pub-id>
        </mixed-citation>
      </ref>
      <ref id="ridm1841176572">
        <label>17.</label>
        <mixed-citation xlink:type="simple" publication-type="book">
          <name>
            <surname>Henshall</surname>
            <given-names>C</given-names>
          </name>
          <name>
            <surname>Ostinelli</surname>
            <given-names>E</given-names>
          </name>
          <name>
            <surname>Harvey</surname>
            <given-names>J</given-names>
          </name>
          <name>
            <surname>Davey</surname>
            <given-names>Z</given-names>
          </name>
          <name>
            <surname>Aghanenu</surname>
            <given-names>B</given-names>
          </name>
          <name>
            <surname>Cipriani</surname>
            <given-names>A</given-names>
          </name>
          <name>
            <surname>Attenburrow</surname>
            <given-names>M J</given-names>
          </name>
          <date>
            <year>2022</year>
          </date>
          <chapter-title>Examining the Effectiveness of Web-Based Interventions to Enhance Resilience in Health Care Professionals: Systematic Review.JMIR Med Educ.8(3):e34230. doi: 10.2196/34230. PMID: 36066962.https://pmc.ncbi.nlm.nih.gov/articles/PMC9490530/</chapter-title>
          <pub-id pub-id-type="doi">10.2196/34230</pub-id>
          <pub-id pub-id-type="pmid">36066962.https://pmc.ncbi.nlm.nih.gov/articles/PMC9490530/</pub-id>
        </mixed-citation>
      </ref>
      <ref id="ridm1841169804">
        <label>18.</label>
        <mixed-citation xlink:type="simple" publication-type="book">
          <name>
            <surname>Di</surname>
            <given-names>Nota PM</given-names>
          </name>
          <name>
            <surname>Bahji</surname>
            <given-names>A</given-names>
          </name>
          <name>
            <surname>Groll</surname>
            <given-names>D</given-names>
          </name>
          <name>
            <surname>Carleton</surname>
            <given-names>R N</given-names>
          </name>
          <name>
            <surname>Anderson</surname>
            <given-names>G S</given-names>
          </name>
          <article-title>Proactive psychological programs designed to mitigate posttraumatic stress injuries among at-risk workers: a systematic review and meta-analysis</article-title>
          <date>
            <year>2021</year>
          </date>
          <chapter-title>Syst Rev .10(1): 126. doi: 10.1186/s13643-021-01677-7. PMID: 33910641 PMCID: PMC8079856 DOI:</chapter-title>
          <fpage>10</fpage>
          <lpage>1186</lpage>
          <pub-id pub-id-type="doi">10.1186/s13643-021-01677-7</pub-id>
          <pub-id pub-id-type="pmid">33910641</pub-id>
        </mixed-citation>
      </ref>
      <ref id="ridm1841158148">
        <label>19.</label>
        <mixed-citation xlink:type="simple" publication-type="book">
          <name>
            <surname>Koontalay</surname>
            <given-names>A</given-names>
          </name>
          <name>
            <surname>Suksatan</surname>
            <given-names>W</given-names>
          </name>
          <name>
            <surname>Prabsangob</surname>
            <given-names>K</given-names>
          </name>
          <name>
            <surname>Sadang</surname>
            <given-names>J M</given-names>
          </name>
          <article-title>Healthcare Workers' Burdens During the COVID-19 Pandemic: A Qualitative Systematic</article-title>
          <date>
            <year>2021</year>
          </date>
          <source>Review.J Multidiscip Healthc</source>
          <chapter-title>10.2147/JMDH.S330041. eCollection 2021. PMID: 34737573 PMCID: PMC8558429 DOI:</chapter-title>
          <volume>14</volume>
          <fpage>3015</fpage>
          <lpage>3025</lpage>
          <pub-id pub-id-type="doi">10.2147/JMDH.S330041</pub-id>
          <pub-id pub-id-type="pmid">34737573</pub-id>
        </mixed-citation>
      </ref>
      <ref id="ridm1841153180">
        <label>20.</label>
        <mixed-citation xlink:type="simple" publication-type="book"><name><surname>Dall'Ora</surname><given-names>C</given-names></name><name><surname>Saville</surname><given-names>C</given-names></name><name><surname>Rubbo</surname><given-names>B</given-names></name><name><surname>Turner</surname><given-names>L</given-names></name><name><surname>Jones</surname><given-names>J</given-names></name><name><surname>Griffiths</surname><given-names>P</given-names></name><article-title>Nurse staffing levels and patient outcomes: A systematic review of longitudinal studies.Int</article-title><date><year>2022</year></date><chapter-title>J Nurs Stud.Oct;134: 104311. doi: 10.1016/j.ijnurstu.2022.104311. Epub</chapter-title>
PMID: 35780608.https://www.sciencedirect.com/science/article/pii/S0020748922001407?via%3Dihub



<pub-id pub-id-type="doi">10.1016/j.ijnurstu.2022.104311</pub-id><pub-id pub-id-type="pmid">35780608.https://www.sciencedirect.com/science/article/pii/S0020748922001407?via%3Dihub</pub-id></mixed-citation>
      </ref>
      <ref id="ridm1841146988">
        <label>21.</label>
        <mixed-citation xlink:type="simple" publication-type="book">
          <name>
            <surname>Silva</surname>
            <given-names>J A</given-names>
          </name>
          <name>
            <surname>Mininel</surname>
            <given-names>V A</given-names>
          </name>
          <name>
            <surname>Fernandes</surname>
            <given-names>Agreli H</given-names>
          </name>
          <name>
            <surname>Peduzzi</surname>
            <given-names>M</given-names>
          </name>
          <name>
            <surname>Harrison</surname>
            <given-names>R</given-names>
          </name>
          <name>
            <surname>Xyrichis</surname>
            <given-names>A</given-names>
          </name>
          <article-title>Collective leadership to improve professional practice, healthcare outcomes and staff (well-being).Cochrane Database of Systematic Reviews</article-title>
          <date>
            <year>2022</year>
          </date>
          <chapter-title>Issue 10. Art. No.: CD013850. DOI: 10.1002/14651858.CD013850.pub2.https://pmc.ncbi.nlm.nih.gov/articles/PMC9549469/pdf/CD013850.pdf</chapter-title>
          <pub-id pub-id-type="doi">10.1002/14651858.CD013850.pub2.https://pmc.ncbi.nlm.nih.gov/articles/PMC9549469/pdf/CD013850.pdf</pub-id>
        </mixed-citation>
      </ref>
      <ref id="ridm1841141588">
        <label>22.</label>
        <mixed-citation xlink:type="simple" publication-type="book">
          <name>
            <surname>Page</surname>
            <given-names>M J</given-names>
          </name>
          <name>
            <surname>McKenzie</surname>
            <given-names>J E</given-names>
          </name>
          <name>
            <surname>Bossuyt</surname>
            <given-names>P M</given-names>
          </name>
          <name>
            <surname>Boutron</surname>
            <given-names>I</given-names>
          </name>
          <article-title>statement: an updated guideline for reporting systematic reviews.BMJ</article-title>
          <date>
            <year>2020</year>
          </date>
          <chapter-title>The PRISMA</chapter-title>
          <pub-id pub-id-type="doi">10.1136/bmj.n71</pub-id>
          <pub-id pub-id-type="pmid">33782057</pub-id>
        </mixed-citation>
      </ref>
      <ref id="ridm1841140580">
        <label>23.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Paré</surname>
            <given-names>G</given-names>
          </name>
          <name>
            <surname>Kitsiou</surname>
            <given-names>S</given-names>
          </name>
          <article-title>Chapter 9 Methods for Literature Reviews inHandbook of eHealth Evaluation: An Evidence-based Approach [Internet]. (Eds Francis Lau and Craig Kuziemsky)</article-title>
          <date>
            <year>2016</year>
          </date>
        </mixed-citation>
      </ref>
      <ref id="ridm1841137340">
        <label>24.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Glaser</surname>
            <given-names>B G</given-names>
          </name>
          <article-title>and Strauss AL.The Discovery of Grounded Theory: Strategies for Qualitative Research.Aldine Transaction;</article-title>
          <date>
            <year>1967</year>
          </date>
          <publisher-loc>New Brunswick</publisher-loc>
        </mixed-citation>
      </ref>
      <ref id="ridm1841132516">
        <label>25.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Strauss</surname>
            <given-names>A</given-names>
          </name>
          <article-title>Corbin J.Basics of qualitative research– techniques and procedures for developing grounded theory, second edition.London: Sage Publications;</article-title>
          <date>
            <year>1998</year>
          </date>
        </mixed-citation>
      </ref>
      <ref id="ridm1841130284">
        <label>26.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Ramalho</surname>
            <given-names>R</given-names>
          </name>
          <name>
            <surname>Adams</surname>
            <given-names>P</given-names>
          </name>
          <name>
            <surname>Huggard</surname>
            <given-names>P</given-names>
          </name>
          <name>
            <surname>Hoare</surname>
            <given-names>K</given-names>
          </name>
          <article-title>Literature review and constructivist grounded theory methodology. Forum Qual Soc Res.16(3):</article-title>
          <date>
            <year>2015</year>
          </date>
        </mixed-citation>
      </ref>
      <ref id="ridm1841127548">
        <label>27.</label>
        <mixed-citation xlink:type="simple" publication-type="journal">
          <name>
            <surname>Barnes</surname>
            <given-names>L MorganBW</given-names>
          </name>
          <name>
            <surname>Parramore</surname>
            <given-names>C S</given-names>
          </name>
          <name>
            <surname>Kaufman</surname>
            <given-names>R B</given-names>
          </name>
          <article-title>Elevated blood lead levels associated with the consumption of moonshine among emergency department patients in Atlanta</article-title>
          <date>
            <year>2003</year>
          </date>
          <source>Georgia.Annals of Emergency</source>
          <volume>42</volume>
          <issue>3</issue>
          <fpage>351</fpage>
          <lpage>358</lpage>
        </mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>
