Moyamoya disease is a circulatory disorder of the brain's blood vessels characterized by irreversible vascular occlusion of the branches of the Circle of Willis. The process of narrowing of cerebral vessels seems to be a reaction of brain blood vessels to a wide variety of external stimuli, injuries, or genetic defects. The process of blockage, once it begins, tends to continue despite any known medical management unless treated with surgery1. It is a very rare disease with a reported incidence of 0.086 per 100,000 populations and it is idiopathic, chronic, and progressive in nature2. The common symptom of Moyamoya is recurrent migraine-like headaches. After a long time, it causes stenosis of intracranial internal carotid arteries resulting the reduced blood supply to the anterior surface of the brain, thereby leading to the formation of collaterals near the apex of carotids3. nani classical literature explains the disease in which partial or complete narrowing of the blood vessels occurs due to yaboosat (dryness) in a particular organ.

A five years old female baby complained of headaches on 11th November 2021. She consulted a pediatrician but was not relieved in the Darbhanga District of Bihar. The doctor suggests a CT scan of the brain and they found a brain hemorrhage. Then she was admitted to a higher neurology center in Patna and after 15 days she got relieved. Then after neuro physician advised for DSA of the brain to rule out any other pathology. The patient went to AIIMS Patna for DSA of the brain and was diagnosed with Moyamoya disease. The neurosurgeon advised the parent of the patient, that only surgical intervention is an option. Then parents came to Unicure Unani Health Care Centre, Patna for alternative and non-invasive, non-surgical treatment.

We advised a Majoon-like compound formulation containing Gule Banafsha (Viola odorata), Ustukhuddoos(Lavandula stoechas), and Nilofer (Nymphaea alba Linn) in equal proportion prepared in honey to administer 3 grams twice daily. She was also advised to take Sikanjbeensada 1 teaspoon twice a day. These all drugs were advised to continue for three months. During the treatment period, she did not have any previous complaints like headaches or seizures. After completion of three months, the patient went for DSA, and then the doctor found that there was not any sign of Moyamoya disease.

The basic pathophysiology of Moyamoya disease is the circulatory deficiency in the brain. This circulatory deficiency results from the progressive narrowing of blood vessels. The precipitating factor for narrowing is not known, genetic and external factors are blamed for it. The only hope for the patient is a surgical intervention for reperfusion of affected brain tissue. Unani medicine relies more on qualities and their effects. Yabusat (dryness) is considered responsible for narrowing and its consequences. The brain reacts differently to the relative ischemia of the Moyamoya phenomenon. The most common manifestation is a migraine-like headache followed by seizures. In severe form, it may cause paralysis.  The parents of under discussion patient refused surgery and decided to opt alternate healing system. The parents with the patient and medical records came to unicure health center Patna. After a thorough study, it was decided to put the patient on such medicine which reduces dryness and removes occlusion if any. For this purpose, Ustukhuddoos (Lavandula stoechas), Gule Banafsha (Viola odorata), and Nilofer (Nymphaea alba Linn) based semisolid preparation was prepared in honey and 5 gm of this was advised orally with 20 ml Sikanjbeensada. Gule Banafsha (Viola odorata) and Nilofer (Nymphaea alba Linn) along ith Sikanjbeensada reduce dryness and produce moisture which overcomes the narrowing of vessels by relaxing them. Ustukhuddoos (Lavandula stoechas), Gule Banafsha (Viola odorata) along with Sikanjbeensada remove vascular occlusion and improve circulation by thinning the blood. They also ease the flow of blood through vessels. Ustukhuddoos (Lavandula stoechas) is one of the drugs of choice for the disease of the brain and the plant has been credited with cephalic virtue and is called “Jarub-i-Dimagh” which means broom of the brain. It is useful to treat many ailments of the brain and nerves like epilepsy, tremor, flaccidity, chorea, migraine, and even concussion of the brain4. Gule Banafsha (Viola odorata) has sedation and pre-anesthetic effects5 effective in migraine headaches6 depression7 inflammation8 and pain9. It is employed as an anti-inflammatory, anodyne, astringent, antiscrophulatic, cardiotonic, demulcent, sedative, and aphrodisiac 101112. In this disease, there is shrinkage or stenosis of blood vessels resulting in the blockage of the blood vessels. The basic pathophysiology of Moyamoya disease is the circulatory deficiency in the brain. This circulatory deficiency results from the progressive narrowing of blood vessels. The precipitating factor for narrowing is not known, genetic and external factors are blamed for it. The only hope for the patient is a surgical intervention for reperfusion of affected brain tissue. Unani medicine relies more on qualities and their effects. Yabusat (dryness) is considered responsible for narrowing and its consequences. The brain reacts differently to the relative ischemia of the Moyamoya phenomenon. The most common manifestation is a migraine-like headache followed by seizures. In severe form, it may cause paralysis.

The cause of the disease is the dry temperament of the particular part of that organ. After treatment, causative factors of the disease have decreased and further, they nourished the affected part of the organ by the drugs having wet temperament.

Informed written consent for publication of clinical details was obtained from the patient