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 <!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.0 20120330//EN" "http://jats.nlm.nih.gov/publishing/1.0/JATS-journalpublishing1.dtd"> <article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="short-communication" dtd-version="1.0" xml:lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">IJCV</journal-id>
      <journal-title-group>
        <journal-title>International Journal of Coronaviruses</journal-title>
      </journal-title-group>
      <issn pub-type="epub">2692-1537</issn>
      <publisher>
        <publisher-name>Open Access Pub</publisher-name>
        <publisher-loc>United States</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.14302/issn.2692-1537.ijcv-22-4108</article-id>
      <article-id pub-id-type="publisher-id">IJCV-22-4108</article-id>
      <article-categories>
        <subj-group>
          <subject>short-communication</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>What Could Represent the Mantissa of the Registered Covid-19 Cases?</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Raúl</surname>
            <given-names>Isea</given-names>
          </name>
          <xref ref-type="aff" rid="idm1850672652">1</xref>
          <xref ref-type="aff" rid="idm1850673012">*</xref>
        </contrib>
      </contrib-group>
      <aff id="idm1850672652">
        <label>1</label>
        <addr-line>Fundación Instituto de Estudios Avanzados, Hoyo de la Puerta, Baruta, Venezuela. </addr-line>
      </aff>
      <aff id="idm1850673012">
        <label>*</label>
        <addr-line>Corresponding author</addr-line>
      </aff>
      <author-notes>
        <corresp>Raúl Isea, Fundación Instituto de, Estudios, Avanzados,, Hoyo, de la Puerta, Baruta, Venezuela. <email>raul.isea@gmail.com</email></corresp>
        <fn fn-type="conflict" id="idm1843379764">
          <p>The authors have declared that no competing interests exist.</p>
        </fn>
      </author-notes>
      <pub-date pub-type="epub" iso-8601-date="2022-03-06">
        <day>06</day>
        <month>03</month>
        <year>2022</year>
      </pub-date>
      <volume>4</volume>
      <issue>2</issue>
      <fpage>1</fpage>
      <lpage>6</lpage>
      <history>
        <date date-type="received">
          <day>21</day>
          <month>02</month>
          <year>2022</year>
        </date>
        <date date-type="accepted">
          <day>02</day>
          <month>03</month>
          <year>2022</year>
        </date>
        <date date-type="online">
          <day>06</day>
          <month>03</month>
          <year>2022</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>© </copyright-statement>
        <copyright-year>2022</copyright-year>
        <copyright-holder>Raúl Isea</copyright-holder>
        <license xlink:href="http://creativecommons.org/licenses/by/4.0/" xlink:type="simple">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
        </license>
      </permissions>
      <self-uri xlink:href="http://openaccesspub.org/ijcv/article/1783">This article is available from http://openaccesspub.org/ijcv/article/1783</self-uri>
      <abstract>
        <p>In this work we present how it is possible to visualize the different coronavirus outbreaks from the calculation of the mantissa from the daily record of cases by Covid-19.This curve can also indicate the speed of propagation of the disease from the calculated <italic>infection rate</italic>. These                  conclusions are derived from the respective                calculations in four different countries: Australia, Brazil, Italy, and Venezuela.</p>
      </abstract>
      <kwd-group>
        <kwd>Mantissa</kwd>
        <kwd>Covid-19</kwd>
        <kwd>Infection rate</kwd>
        <kwd>Outbreaks</kwd>
      </kwd-group>
      <counts>
        <fig-count count="4"/>
        <table-count count="0"/>
        <page-count count="6"/>
      </counts>
    </article-meta>
  </front>
  <body>
    <sec id="idm1850521428" sec-type="intro">
      <title>Introduction</title>
      <p>Isea proposed a new graphical                        representation to be able to visualize the different epidemic outbreaks from the calculation of the mantissa obtained from the daily Covid-19             cases <xref ref-type="bibr" rid="ridm1850765820">1</xref><xref ref-type="bibr" rid="ridm1850769564">2</xref><xref ref-type="bibr" rid="ridm1850846172">3</xref>. This calculation made it possible to explain the different outbreaks that occurred in            Venezuela from March 15 to September 9,            2020 <xref ref-type="bibr" rid="ridm1850846172">3</xref>.  </p>
      <p>We propose that the calculation of the               mantissa may be associated with the propagation spread of infections by Covid-19, similar to <italic>infection rate</italic>. Let us remember that traditionally the <italic>infection rate</italic> is usually a constant value that quantifies the infection rate of disease <xref ref-type="bibr" rid="ridm1850621772">4</xref>.  </p>
      <p>For this reason, we are going to obtain a mathematical expression that will determine the time-dependent <italic>infection rate</italic> according to the SIR                 compartmental model, and evaluate it numerically to show the association with the mantissa obtained from the registry of daily cases. </p>
      <p>This calculation is very simple to do, and it can even be done from a cell phone, with the                 limitation that is valid only if the total number of       people is representative in the country (details in the work methodology). Finally, we evaluated four               different countries, <italic>ie</italic><italic>.,</italic> Australia, Brazil, Italy, and Venezuela, corresponding to different moments of the Covid-19 pandemic</p>
    </sec>
    <sec id="idm1850520348" sec-type="methods">
      <title>Methodology </title>
      <p>This paper presents the possibility of being able to associate the epidemic outbreaks Covid-19 with the <italic>infection rate</italic> obtained from the calculation of the mantissa according to the systematic                      registration of cases by Covid-19. To do that, we will first calculate the mantissa of infected cases, and later on, an expression of the type of the infection rate according to the SIR compartmental model.</p>
      <sec id="idm1850519196">
        <title>Mantissa Calculation</title>
        <p>This methodology has been used in several            scientific publications <xref ref-type="bibr" rid="ridm1850765820">1</xref><xref ref-type="bibr" rid="ridm1850769564">2</xref><xref ref-type="bibr" rid="ridm1850846172">3</xref>, it means, from the daily              record of cases by Covid-19 obtained from Johns Hopkins University (coronavirus.jhu.edu), we calculated the               mantissa, abbreviated as M(t) according to the following equation:</p>
        <fig id="idm1842083132">
          <graphic xlink:href="images/image1.png" mime-subtype="png"/>
        </fig>
        <p>Where <italic>I</italic><sub><italic>i</italic></sub><italic>(t) </italic>is the cumulative confirmed Covid-19 cases by world region in a time t,  <italic>log</italic><sub><italic>10</italic></sub><italic>(</italic><italic>I</italic><sub><italic>i</italic></sub><italic>(t) </italic>is the                  logarithm evaluated to the base ten, while that <italic>(</italic><italic>I</italic><sub><italic>i</italic></sub><italic>(t) </italic>represents the integer part of the numerical result.</p>
        <p>Let us remember that the values ​​of the mantissa range from zero to one, where a value of zero corresponds to the absence of an epidemic outbreak, while a value of one corresponds to a high rate of spread of Covid-19               infections in this country.</p>
      </sec>
      <sec id="idm1850508684">
        <title>Calculation of the Infection Rate</title>
        <p>We are going to determine a mathematical               expression capable of quantifying the infection rate,             traditionally abbreviated as <italic>β</italic>, based on the                            time-dependence SIR compartimental model. To do this, we remember the differential equations initially proposed by Kermack and McKendrick in 1927 <xref ref-type="bibr" rid="ridm1850628252">5</xref>, whose analytical solution was recently explained in recent years <sup>see for example 6</sup></p>
        <fig id="idm1842085220">
          <graphic xlink:href="images/image2.png" mime-subtype="png"/>
        </fig>
        <p>where the constants <italic>β</italic><italic>, </italic><italic>γ</italic><italic>, N </italic>represent the infection rate, recovery rate, and the total number of people,                 respectively.  This model considers the total population is susceptible to contracting this disease <italic>S(t)</italic>, and only a  fraction can be infected, <italic>I(t)</italic> according to infection rate defined by <italic>β</italic>. Finally, the    population recovers, <italic>R(t)</italic>, at a recovered rate given by <italic>γ</italic>; with the condition that</p>
        <fig id="idm1842065308">
          <graphic xlink:href="images/image3.png" mime-subtype="png"/>
        </fig>
        <p>We are going to study the dynamics of contagion in entire countries. By considering the following approximation <italic>S(t)</italic><italic>≈</italic><italic>N </italic>and substituting it into                equation (3), we can obtain an expression for <italic>γ(</italic><italic>t),</italic> given by:</p>
        <fig id="idm1842063940">
          <graphic xlink:href="images/image4.png" mime-subtype="png"/>
        </fig>
        <p>So the expression to get the infection rate <italic>β(</italic><italic>t)</italic> will be simply:</p>
        <fig id="idm1842070708">
          <graphic xlink:href="images/image5.png" mime-subtype="png"/>
        </fig>
        <p>As can be seen in the previous equation (5), the calculation of the infection rate only depends on the cases infected and recovered over time.</p>
      </sec>
    </sec>
    <sec id="idm1850496644" sec-type="results">
      <title>Results</title>
      <p>The daily record of cases by Covid-19 was                  obtained from the database managed by Johns Hopkins University, and we will only consider four countries:           Australia, Brazil, Italy, and Venezuela. From these values, we calculated the value of the mantissa according to               equation (1) and later the infection rate according to equation (5). The results can be seen in <xref ref-type="fig" rid="idm1842045332">figure 1</xref>, <xref ref-type="fig" rid="idm1842042236">Figure 2</xref>, <xref ref-type="fig" rid="idm1842044036">Figure 3</xref>, and <xref ref-type="fig" rid="idm1842039788">Figure 4</xref> corresponding to Australia, Brazil, Italy, and Venezuela, respectively. In these figures, the calculation of the                mantissa is represented in green, while the infection rate is in blue.</p>
      <fig id="idm1842045332">
        <label>Figure 1.</label>
        <caption>
          <title> Calculation of the values ​​of the mantissa (green color) and the infection rate (blue) of the          cases registered by Covid-19 in Australia.</title>
        </caption>
        <graphic xlink:href="images/image6.jpg" mime-subtype="jpg"/>
      </fig>
      <fig id="idm1842042236">
        <label>Figure 2.</label>
        <caption>
          <title> Calculation of the values ​​of the mantissa (green color) and the infection rate (blue) of the  cases registered by Covid-19 in Brazil.</title>
        </caption>
        <graphic xlink:href="images/image7.jpg" mime-subtype="jpg"/>
      </fig>
      <fig id="idm1842044036">
        <label>Figure 3.</label>
        <caption>
          <title> Calculation of the values ​​of the mantissa (green color) and the infection rate (blue) of the cases  registered by Covid-19 in Italy.</title>
        </caption>
        <graphic xlink:href="images/image8.jpg" mime-subtype="jpg"/>
      </fig>
      <fig id="idm1842039788">
        <label>Figure 4.</label>
        <caption>
          <title> Calculation of the values ​​of the mantissa (green color) and the infection rate (blue) of the cases  registered by Covid-19 in Venezuela.</title>
        </caption>
        <graphic xlink:href="images/image9.jpg" mime-subtype="jpg"/>
      </fig>
      <p><xref ref-type="fig" rid="idm1842045332">Figure 1</xref> shows the result obtained in Australia (one of the first countries where the pandemic spread), and we can observe an outbreak in March 2020, followed by other in July of the same year. These moments are              precisely two periods where the Covid-19 affected that country. Finally, another infectious focus began to be         registered towards the end of the year associated (mainly) with the variant called Omicron.</p>
      <p><xref ref-type="fig" rid="idm1842045332">Figure 1</xref> also shows three complete cycles in the calculation of the mantissa, that is, three different                 beginnings where the values varies from zero to one. We call them a Mantissa propagation cycle. The first began from March to August, the second from August to October, and finally the last until January 2022.  It is interesting to mention that the calculation of the mantissa coincides at those moments to high values ​​of the infection rate             obtained with equation (5). Hence, we can associate the mantissa of cases with epidemic outbreaks without being able to differentiate which variant it corresponds to.</p>
      <p>The results obtained in the case of Brazil are shown in <xref ref-type="fig" rid="idm1842042236">Figure 2</xref>. Unlike Australia, in the first months in Brazil there were multiple outbreaks (green color). These variations are also observed in the calculation of the               infection rate (in blue) until October 2020, when the                 country begins to overcome this pandemic. Later, in             January 2021, it can be seen how the infection rate                  fluctuates around a constant value until the end of                  February 2021.This value probably represents a dominant variant in this country.In addition, you can see how fast the virus spread in Brazil in the first half of 2020 (blue curve).</p>
      <p>The results in the case of Italy are shown in           <xref ref-type="fig" rid="idm1842044036">Figure 3</xref>. We observed an increase in the mantissa curve in March 2020, which corresponds to a significant increase in cases in the country, and this country had to impose a series of lockdowns to stop these epidemic outbreaks. Moreover, the authorities prohibited any physical activity in the country until March 22, 2021, and this period was later extended until May 3. From May 4, a series of measures began that relaxed the confinement measures until October and it is surprising that this behavior is also observed in the mantissa graph (<xref ref-type="fig" rid="idm1842044036">Figure 3</xref>). Towards the end of November of last year, Italy detected the Omicron               variant and it is again reflected in the mantissa graph.On the other hand, we can see the speed of spread in Covid-19 cases in the first quarter of 2020 (blue curve).</p>
      <p>Finally, the results obtained in Venezuela can be seen in <xref ref-type="fig" rid="idm1842039788">figure 4</xref>. We can see that the mantissa of the Covid cases is completely different from the rest of the countries, probably due to the lockdown scheme called "7+7", it means, seven days out of quarantine where there was no type of activity allowed in the country, and later on, seven days where only social distancing and the use of face masks were imposed. Thanks to this, by the end of                 November 2020 there were no longer significant                   outbreaks, and there was only an increase due to the       presence of other strains of the virus. The speed of spread of the virus in Venezuela is lower than the rest of the countries previously studied.</p>
    </sec>
    <sec id="idm1850499956" sec-type="conclusions">
      <title>Conclusion</title>
      <p>This paper presents a graphic representation that can help to visualize the different outbreaks by Covid-19 from the calculation of the mantissa. Also, an idea of ​​the speed of spread of this disease in these countries can be derived. This assumption is in accordance with a                mathematical expression that presents the infection rate dependent-time according to the SIR model. In fact, this type of calculation has the advantage of being able to             visually identify the control measures carried out by a government as well as being able to generate alerts in the case of increases that can generate new outbreaks.</p>
    </sec>
    <sec id="idm1850498660">
      <title>Dedicatory</title>
      <p>This work is dedicated to all the people who work in medical services who continually expose their lives to help recover all those people who are being infected by this pandemic.</p>
    </sec>
    <sec id="idm1850498876">
      <title>Acknowledgment</title>
      <p>I’d like to acknowledgment to Rafael Mayo-Garcia by your help and patience in read and comments this    manuscript. </p>
    </sec>
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